The Man Called Flintstone
The point is arguably made, anyway. Under Silverman, the network committed to such successes as St. Elsewhere, Cheers, Diff'rent Strokes, The Facts of Life, Gimme A Break, the landmark mini-series Shogun, and a little cop drama called Hill Street Blues.
The Man Called Flintstone
The very appellation intervertebral for the cushion that gives the spinal column its remarkable resilience and mobility is a classic example of CIFOTHISM. By the 8th week of intrauterine life, every single "disc" is fully manifest, without a spicule of bone in the vertebrae, which develop later. Further, each disc is coplanar with its somite, compelling you to declare that each vertebral body is interdiscal, and each so-called intervertebral foramen fashions itself around the preformed spinal nerve which in no way "enters" the foramen or "exits" therefrom. The biplanarness of a "disc" has to be replaced by the 3D nature of it, urging you to call it a cushion of the back, or the pulvinot. Its collagen dutifully records the age of the person. The disc does not "degenerate" but exhibits changes consistent with age, as graying hair does. To tell a person of 70 years of age that his/her pulvinot is 70 years old is far less iatrogenic and insulting than to condemn it as degenerate.
The neuroglial cells outnumber neurons tenfold. They are essentially not interneuronal glue (hence called neuroglia) but perineural to form neuron-tight insulation, and hence fit to be called insulocytes. The smaller varieties of "neuroglial" cells are intermediates between the neurone's nutrition and the proximate capillary, hence better called intermediocytes. The real glue that separates a neuron from another neuron or neuroglial cells is the universal and ubiquitous neuroqua. A more preferable name for neurogliocyts would be clinocytes (from klinos = bed) for they form a huge bed in which the neurons are clothed, rested, and nourished.
What we have overlooked is the so-called immunological (more correctly reactivological) factor. When the thymus is maturingin utero, dividing cells from all over the fetus, present their credentials to the thymus, whereby it eliminates the lymphocytic clones that may unleash possible reaction against these cells in future. The lymphocytic cells so eliminated are the forbidden clones that the Nobelist Burnet first postulated in 1947, and were later proved to be so by Medawar, both getting the Nobel in 1960. Neurons being indivisible cannot placate the fetal thymus, which thus always harbors clones that can let loose a vicious reaction against one's neuronal cells to occasion the so-called auto-immune encephalomyelitis. The net outcome of this situation is that should the neuronal protein be leaked into circulation, while a neuraxial wound is healing, it can cause damage much greater than that inflicted by the injury. This is evident from sympathetic ophthalmitis where injury to one side uveal tract can lead to the reactive destruction of not only that eye but even the other uninjured eye. In most likelihood, Nature while repairing a neuraxial wound, first sees to it that no neuronal multiplication occurs whereby the thymus may have a taste of the neuraxial protein to precipitate a pan neuraxial crisis. Can it not be the reason why no neuron has direct access or proximity to capillary circulation, the two being widely separated by intermediocytes (or the smaller neurglial cells), the stem cell dream is likely to remain a dream, and that too for the right reasons. 041b061a72